Results are the measure of regenerative medicine.

Let results lead.

01 — About Dafan

Verifiable. Scalable. Trusted.

Dafan Health is built at the intersection of extracellular vesicle biology and stem cell science. We believe that trust in medicine begins with honest data, and that the value of innovation lies in reproducible results. Every decision returns to the scientific fundamentals — quantifiable, verifiable, trusted.

Results Define Value

Clinical outcomes define the standard for regenerative medicine. We believe the value of regenerative medicine must be built on verifiable clinical results. Every cellular application should have traceable data and long-term observational records.

Science Becomes Capability

We build standardized cell manufacturing and quality systems, giving cellular applications a measurable and reproducible foundation. Clinical tracking and data monitoring allow medical decisions to be grounded in reliable data.

From Research to Clinical

We connect cell research, bioprocessing, and clinical medicine to build regenerative medicine capabilities that can be applied clinically. Taking regenerative medicine from research to monitorable clinical application.

Results Define Value

Science Becomes Capability

From Research to Clinical

02 — Milestones

A Traceable Journey

1989.07

Applied autologous stem cells to periodontal disease treatment.

1997.01

Applied autologous stem cell transplantation technology to burn treatment.

2009.05

Industry-academia collaboration with USC professor; paper published in Oral Diseases international journal, receiving the 2010 Best Original Paper Award.

2020.11

Dafan Health Co., Ltd. officially established. Development goals for 2025–2026 set as obtaining GTP certification and forming partnerships with major regional hospitals.

Years of Clinical Research

Healthcare Partners

03 — Clinical Evidence

Data is the language of science.

Evidence-Based. Peer-Reviewed.

Academic Contribution · 01

Autologous Transplantation of Gingival Fibroblast-Like Cells and a Hydroxylapatite Complex Graft in the Treatment of Periodontal Osseous Defects: Cell Cultivation and Long-Term Report of Cases

Autologous gingival fibroblast-like cells were cultured and combined with a hydroxylapatite complex graft for periodontal osseous defect treatment. Cell cultivation protocols are described alongside long-term clinical follow-up, demonstrating the feasibility of autologous cell-based approaches for periodontal bone regeneration.

Hou, L.-T. et al.
Cell Transplantation 2003Read Paper

Academic Contribution · 02

Utility of PDL Progenitors for In Vivo Tissue Regeneration: A Report of 3 Cases

Three clinical cases examined the therapeutic utility of periodontal ligament (PDL) progenitor cells for in vivo tissue regeneration. Results demonstrated successful engraftment and regenerative outcomes at periodontal defect sites, supporting the clinical potential of autologous PDL-derived progenitor populations.

Feng, F. et al.
Oral Diseases 2009Read Paper

Academic Contribution · 03

Enhanced Chondrogenic Differentiation Potential of Human Gingival Fibroblasts by Spheroid Formation on Chitosan Membranes

Human gingival fibroblasts cultured as three-dimensional spheroids on chitosan membranes exhibited significantly enhanced chondrogenic differentiation capacity versus monolayer culture. Upregulation of collagen type II and aggrecan confirmed phenotypic shift toward chondrocytes, establishing a scaffold-based strategy to reprogram gingival cells for cartilage tissue engineering.

Hsu, S.-H. et al.
Tissue Engineering Part A 2011Read Paper

Academic Contribution · 04

Isolation of the Multipotent MSC Subpopulation from Human Gingival Fibroblasts by Culturing on Chitosan Membranes

Chitosan membrane culture selectively expanded a multipotent mesenchymal stem cell (MSC) subpopulation from primary human gingival fibroblasts. The isolated cells expressed canonical MSC surface markers and retained trilineage differentiation capacity (osteogenic, chondrogenic, adipogenic), identifying gingival tissue as an accessible and ethically favorable source for clinical MSC applications.

Hsu, S.-H. et al.
Biomaterials 2012Read Paper

Academic Contribution · 05

Exosome Therapy for Livedoid Vasculitis Following COVID-19 Vaccination: A Case Report

This case report describes the use of exosome therapy in a patient with livedoid vasculitis refractory to conventional treatment following COVID-19 vaccination. Significant clinical improvement was observed after exosome administration, with complete lesion resolution at three months, suggesting exosome-based immunomodulation as a novel approach for post-vaccination inflammatory vascular conditions.

Lin, T.-K. et al.
Drug Healthc Patient Saf. 2026Read Paper

Years of Clinical Research

Healthcare Partners

03 — Clinical Evidence

Data is the language of science.

Evidence-Based. Peer-Reviewed.

Academic Contribution · 01

Autologous Transplantation of Gingival Fibroblast-Like Cells and a Hydroxylapatite Complex Graft in the Treatment of Periodontal Osseous Defects: Cell Cultivation and Long-Term Report of Cases

Hou, L.-T. et al.
Cell Transplantation 2003Read Paper

Academic Contribution · 02

Utility of PDL Progenitors for In Vivo Tissue Regeneration: A Report of 3 Cases

Feng, F. et al.
Oral Diseases 2009Read Paper

Academic Contribution · 03

Enhanced Chondrogenic Differentiation Potential of Human Gingival Fibroblasts by Spheroid Formation on Chitosan Membranes

Hsu, S.-H. et al.
Tissue Engineering Part A 2011Read Paper

Academic Contribution · 04

Isolation of the Multipotent MSC Subpopulation from Human Gingival Fibroblasts by Culturing on Chitosan Membranes

Hsu, S.-H. et al.
Biomaterials 2012Read Paper

Academic Contribution · 05

Exosome Therapy for Livedoid Vasculitis Following COVID-19 Vaccination: A Case Report

Lin, T.-K. et al.
Drug Healthc Patient Saf. 2026Read Paper

04 — Founder

Academic and Clinical Perspectives, United.

Academics & Clinicians, Together.

Feng Fuh, M.D.

Founder

With a deep background in regenerative medicine clinical practice and research, dedicated to translating extracellular vesicle and stem cell science into trusted medical solutions. Founded Dafan Health with scientific rigor and medical ethics at its core, leading the team to advance the accessibility and standardization of regenerative medicine, enabling breakthrough therapies to truly benefit more patients.

Regenerative MedicineCell TherapyHealthcare Management

05 — Organization

Organized Around Science.

Structure & Governance

Dafan

Operations & Administration
- Finance
- Human Resources
- Legal
- Chairman's Office
R&D & Production
- Research & Development
- Process Engineering
- Quality Control
- Facilities
Marketing & Sales
- Marketing
- Sales

Dafan

Operations & Administration
- Finance
- Human Resources
- Legal
- Chairman's Office
R&D & Production
- Research & Development
- Process Engineering
- Quality Control
- Facilities
Marketing & Sales
- Marketing
- Sales

06 — Focus Areas

Our Areas of Medical Focus

Dafan Health is focused on the translational application of regenerative medicine in chronic diseases and degenerative conditions, grounding extracellular vesicle and stem cell science in trusted clinical solutions, committed to closing the gap between fundamental research and patient benefit.

01Periodontitis

02Osteoarthritis

03Glaucoma

04Macular Degeneration

05Chronic Vasculitis

06Alzheimer's Disease

07Parkinson's Disease

08Type 2 Diabetes

09Chronic End-Stage Kidney Disease

10Medical Aesthetics & Skincare

07 — Research Contribution

Global Chronic Disease Impact

These are the numbers Dafan Health is working to change.

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Obesity

Type 2 Diabetes

Alzheimer's Disease

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Chronic Kidney Disease

Macular Degeneration

Metabolic Syndrome