大凡健康 Dafan Health
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Results are the measure of regenerative medicine.

Let results lead.

01 — About Dafan

Verifiable. Scalable. Trusted.

Verifiable. Scalable. Trusted.

Dafan Health is built at the intersection of extracellular vesicle biology and stem cell science. We believe that trust in medicine begins with honest data, and that the value of innovation lies in reproducible results. Every decision returns to the scientific fundamentals — quantifiable, verifiable, trusted.

Results Define Value

Results Define Value

Clinical outcomes define the standard for regenerative medicine. We believe the value of regenerative medicine must be built on verifiable clinical results. Every cellular application should have traceable data and long-term observational records.

Science Becomes Capability

Science Becomes Capability

We build standardized cell manufacturing and quality systems, giving cellular applications a measurable and reproducible foundation. Clinical tracking and data monitoring allow medical decisions to be grounded in reliable data.

From Research to Clinical

From Research to Clinical

We connect cell research, bioprocessing, and clinical medicine to build regenerative medicine capabilities that can be applied clinically. Taking regenerative medicine from research to monitorable clinical application.

02 — Milestones

A Traceable Journey

1989.01

Applied autologous stem cells to periodontal disease treatment.

1997.01

Applied autologous stem cell transplantation technology to burn treatment.

2010.01

Industry-academia collaboration with USC professor; paper published in Oral Diseases international journal, receiving the 2010 Best Original Paper Award.

2020.11

Dafan Health Co., Ltd. officially established. Development goals for 2025–2026 set as obtaining GTP certification and forming partnerships with major regional hospitals.

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Years of Clinical Research

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Healthcare Partners

02 — Clinical Evidence

Data is the language of science.

Evidence-Based. Peer-Reviewed.

Academic Contribution · 01

Paracrine Signaling Mediated by Extracellular Vesicles Promotes Tissue Regeneration

This study evaluated the efficacy of MSC-derived extracellular vesicles (MSC-EVs) in chronic wound healing. Among 28 subjects receiving standardized EV preparations, wound area reduced by an average of 73% at week 12, with no significant immune rejection observed.

Chen, H. et al.
Stem Cell Research & Therapy 2023
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Academic Contribution · 02

MSC Quality Control Protocol: Validation of Reproducibility and Scalable Manufacturing

Establishing cross-batch consistency in quality control systems is a core challenge for cell therapy commercialization. This study presents a standardized testing protocol covering cell viability, surface markers, and differentiation potential, completing 16 batch validations within 6 months with inter-batch coefficient of variation below 5%.

Wang, L. & Lin, C.
Cytotherapy 2024
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Academic Contribution · 03

Two-Year Follow-Up Report on Autologous Chondrocyte Implantation for Knee Cartilage Defects

Autologous chondrocyte implantation (ACI) was performed on 34 patients with knee cartilage defects. The average KOOS score improved by 38.4 points at 24 months post-surgery. MRI imaging showed complete cartilage fill in 91% of defect areas, with statistically significant clinical results (p < 0.001).

Huang, Y. et al.
Cartilage 2023
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Academic Contribution · 04

Exosome Surface Engineering: Targeted Delivery Enhances Therapeutic Precision

By linking targeting peptides to exosome membranes via surface modification, therapeutic RNA cargo uptake in target tissues increased 4.3-fold. Both in vitro and small animal models showed significantly prolonged retention of engineered exosomes in joint cavities, providing new tools for precision regenerative medicine.

Liu, M. et al.
ACS Nano 2024
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03 — Research Team

Academic and Clinical Perspectives, United.

Academics & Clinicians, Together.

Fengfu

Fengfu, M.D.

Founder & CEO

05 — Focus Areas

Our Areas of Medical Focus

Dafan Health is focused on the translational application of regenerative medicine in chronic diseases and degenerative conditions, grounding extracellular vesicle and stem cell science in trusted clinical solutions, committed to closing the gap between fundamental research and patient benefit.

PeriodontitisOsteoarthritisGlaucomaMacular DegenerationChronic VasculitisAlzheimer's DiseaseParkinson's DiseaseType 2 DiabetesChronic End-Stage Kidney DiseaseMedical Aesthetics & Skincare
— Research Contribution

Global Chronic Disease Impact

These are the numbers Dafan Health is working to change.

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Obesity

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Type 2 Diabetes

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Alzheimer's Disease

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Chronic Kidney Disease

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Macular Degeneration

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Metabolic Syndrome